Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary. 1st Department of Internal Medicine, Semmelweis University, 26 Üllői Street, Budapest, 1085, Hungary. Public Health & Preventive Medicine, Oregon Health & Science University, 3184 S.W. Sam Jackson Park Rd, CB669, Portland, OR, 97329, USA. Department of Neurology, Oregon Health & Science University, 3184 S.W. Sam Jackson Park Rd, L603, Portland, OR, 97329, USA. Department of Neurology, Oregon Health & Science University, 3184 S.W. Sam Jackson Park Rd, L603, Portland, OR, 97329, USA. neuwelte@ohsu.edu. Department of Neurosurgery, Oregon Health & Science University, 3184 S.W. Sam Jackson Park Rd, L603, Portland, OR, 97329, USA. neuwelte@ohsu.edu. Portland Veterans Affairs Medical Center, 3710 S.W. US Veterans Hospital Rd, Portland, OR, 97239, USA. neuwelte@ohsu.edu. Blood-Brain Barrier and Neuro-Oncology Program, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, L603, Portland, OR, 97239, USA. neuwelte@ohsu.edu.